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Ipecac Fluid Extract 2% Emetin
Botanical Name: Cephaelis ipecacuanha
Common Names: Ipecacuanha fluid extract
Cautions: Do not use the root or rhizome, except under knowledgeable guidance.
Take formulations containing ipecac fluid extract carefully and only as instructed
on the label. Deaths have resulted from overdose.
Do not use over an extended period of time as it can lead to myopathias.
Frequent use can lead to allergic reactions.
Do not use during pregnancy.
Ipecac fluid extract came to Europe in 1672 and achieved fame as a cure
for dysentery. This controversial remedy appeared to work well in some cases,
but had no effect in others. Today, we understand that there are two types of
dysentery -- amebic and bacillary. While the herb acts strongly against amebas,
it has little effect on bacilli.
Key Actions: antiamebic, emetic, expectorant, spasmolytic
Traditional Uses of Ipecac fluid extract:
Used in both conventional and herbal medicine, ipecac is listed in most national
pharmacopoeias as being one of the surest of emetics and, even moderate doses,
will stimulate vomiting until the contents of the stomach are cleared. It is
particularly useful in drug overdose. In lower doses, it is a strong expectorant
and commonly found in many patent cough medicines and used in the treatment
of bronchitis and whooping cough. As an expectorant, it soothes and assists in
coughing up thick phlegm, especially in children.
It is also very effective for amebic dysentery.
Homeopathic remedies are used to treat bronchitis, asthma, whooping cough,
gastrointestinal inflammations, blood pressure disorders, and mucous membrane
bleeding. Higher doses are used as an emetic.
For more information about purchasing
The IPECAC FLUID EXTRACT 2% EMETIN
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Certificate of Analysis - C.O.A.
CERTIFICATE OF ANALYSIS – C.O.A
Product: IPECAC FLUID EXTRACT 2% EMETIN
Prep. Date: Sep 09
CONTAINS: Ipecac extract – Water Type 1 – Ethyl Alcohol extra neutral
APPEARANCE: A dark brown colored liquid with a characteristic aroma
DISCRIPTION: A liquid preparation obtained by extracting powdered of
Ipecacuanha root with ethanol to obtain a standardized level of alkaloids
(1,90% to 2.10% calculated as emetine)
SOLUBLE: In water and alcohol
Ipecacuanha Liquid Extract is used in: syrup preparation, as an expectorant,
an emetic. It is frequently incorporated into liquid cough preparations and widely
used by pharmaceutical industries.
STORAGE PRECAUTIONS: Avoid exposure to heat
MATERIAL VOLUME: Class A, according to applicable international normatively
BALANCE: Calibrated due to quality norm to traceable weights
PACK TYPE: Containers of: 10, 20, 30, 50 L homologated plastic drums
SHELF LIFE: Shelf life for unopened containers is 2 years
PHYSICAL – CHEMICAL CHARACTERISTICS:
CP calculated as emetine: 2.10% (EMETINE 1.12 + CEPHAELINE 0.98 mg/100 ml)
Presence of alkaloids: Positive
Color brown fluid liquid: Complies
Solution aspect: s/e
Stability: Stable (X) Unstable ( )
Relative density: 0.940
Ethanol content (GL): 34% - 36%
Foreign element: s/e
Specific Gravity 25 C: 1.004
As 0.860 ppm
Pb 0.250 ppm
Cd 0.180 ppm
Hg 0.350 ppm
Compliance USP 467 Residual solvents: ( no residual solvents to be present)
Compliance ICH guidance Q3C Impurities
Yeast 0 – 100 = 10 cpg
Mold 0 – 100 = 10 cpg
Gran Negatives Absent is 1 ml (IT2 – 046)
Pseudomonas aeruginosa Absent is 10 ml (IT2 – 047)
Escherichia Coli Absent in 10 ml (IT2 – 047)
Salmonella sp Absent in 10 ml (IT2 – 047)
Take 5 ml of liquid extract
Add 20 ml water and 5 ml sulphuric acid snake well,
Extract with 10 ml chloroform three times
Add a mixture of 4 ml of ethanol (96%) and 20 ml of 0.05 M sulphuric acid shake well and discard the chloroform extract.
Combine the acid liquid, make it alkaline with NH3 and extract with chloroform several times, until complete extraction of alkaloids is effected.
Wash each chloroform extract with same 10 ml water, combine the chloroform liquid and filter the chloroform extract
Add 2 ml alcohol to the residue and evaporate it to dryness.
Keep it in dry places for 10 mins, at 80ºC. Dissolve it in 10 ml of 0.05M HCL, titrate with 0.1M sodium hydroxide by using methyl red solution one to two drops as indicator.
Each ml of 0.1M sulphuric acid is equivalent to 24.03 mg of C29H4004n2. It contains alkaloids calculated with reference to the C29H4004N2, about 1.9-2.1%